منابع مشابه
Epigenetic germline mosaicism in infertile men.
Imprinted genes are expressed either from the paternal or the maternal allele, because the other allele has been silenced in the mother's or father's germline. Imprints are characterized by DNA methylation at cytosine phosphate guanine sites. Recently, abnormal sperm parameters and male infertility have been linked to aberrant methylation patterns of imprinted genes in sperm DNA. However, these...
متن کاملGenetic and Epigenetic landscape of Germline Stem Cells
Elucidating the critical epigenetics events involved in differentiation and reprogramming of cells to primordial germ cells (PGCs) is among the interesting issues in stem cell research. Here, I will talk about critical transcription factors and global hypomethylation in development of germ cells. Evidence strongly suggests that the earliest PGCs emerging in the E7.25 mouse embryo epiblast have...
متن کاملAltered histone retention and epigenetic modifications in the sperm of infertile men.
I t is well know that the nuclei of spermatogenic cells experience one of the most extremely marked chromatin changes known in cells. At the end of spermatogenesis, the histones are removed in many species and the DNA is condensed by the highly positively charged protamines forming highly compact nucleoprotamine complexes. In the human mature sperm cell, the nucleoprotamine complexes condense m...
متن کاملIdentity suffering in infertile men
The suffering caused by infertility in a man can have multiple aspects. It can display a narcissistic dimension, an objectal dimension (object-libido) turned toward others or/and an identity dimension. Two clinical case reports were used here to (i) illustrate all these aspects of infertility suffering, (ii) to evidence the difficulty for infertile men to speak about their infertility and (iii)...
متن کاملFirst description of germline mosaicism in familial hypertrophic cardiomyopathy.
Familial hypertrophic cardiomyopathy is a genetically and phenotypically heterogeneous disease caused by mutations in seven sarcomeric protein genes. It is known to be transmitted as an autosomal dominant trait with rare de novo mutations.A French family in which two members are affected by hypertrophic cardiomyopathy was clinically screened with electrocardiography and echocardiography. Geneti...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2014
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddu540